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           Cimini Lab   Department of Biological Sciences

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Publications



Chromosome Segregation and Chromosome Instability
  Chromosomes missegregated into micronuclei contribute to chromosomal instability by missegregating
       at the next division.

       He B., Gnawali N., Hinman A.W., Mattingly A.J., Osimani A., Cimini D. (2019).
       Oncotarget, 10: 2660-2674.

  Exogenous glucocorticoids amplify the costs of infection by reducing resistance and tolerance,
       but effects are mitigated by co-infection.

       Schoenle L.A., Moore I.T., Dudek A.M., Garcia E.B., Mays M., Haussmann M.F., Cimini D., Bonier F. (2019).
       Proceedings of the Royal Society B: Biological Sciences, 286: 20182913.

  Single-cell analysis reveals that chronic silver nanoparticle exposure induces cell division defects
       in human epithelial cells.

       Garcia E.B., Alms C., Hinman A.W., Kelly C., Smith A., Vance M., Loncarek J., Marr L.C., Cimini D. (2019).
       International Journal of Environmental Research and Public Health, 16: 2061.

  Environmental stresses induce karyotypic instability in colorectal cancer cells.
       Tan Z., Chan Y.J.A., Chua Y.J.K., Rutledge S.D., Pavelka N., Cimini D., Rancati G. (2019).
       Molecular Biology of the Cell, 30: 42-55.

  Chromosome segregation: the bigger they come, the harder they fall.
       Baudoin N.C. and Cimini D. (2018).
       Current Biology, 28: R665–R667.

 A guide to classifying mitotic stages and mitotic defects in fixed cells.
       Baudoin N.C. and Cimini D. (2018).
       Chromosoma, 127: 215-227.

 Fluid shear stress impacts ovarian cancer cell viability, subcellular organization, and promotes
       genomic instability.

       Hyler A.R., Baudoin N.C., Brown M.S., Stremler M.A., Cimini D., Davalos R.V., Schmelz E.M. (2018).
       PLoS ONE, 13: e0194170.

 Near-tetraploid cancer cells show chromosome instability triggered by replication stress and exhibit
       enhanced invasiveness.

       Wangsa D., Quintanilla I., Torabi K., Vila-Casadesús M., Ercilla A., Klus G., Yuce Z., Galofré C.,
       Cuatrecasas M., Lozano J.J., Agell N., Cimini D., Castells A., Ried T., and Camps J. (2018).
       FASEB Journal, 3502-3517.

 Transient ALT activation protects human primary cells from chromosome instability induced by
       low chronic oxidative stress.

       Coluzzi E., Buonsante R., Leone S., Asmar A.J., Miller K.L., Cimini D., and Sgura A. (2017).
       Scientific Reports, 7: 43309.

 Chromosome bridges maintain kinetochore-microtubule attachments throughout mitosis
       and rarely break during anaphase.

       Pampalona J., Roscioli E., Silkworth W.T., Bowden B., Genescà A., Tusell L., and Cimini D. (2016)
       PLoS ONE, 11:e0147420.

 The centrosome: a multifaceted cellular weapon against chromosome instability.
       Guarguaglini G. and Cimini D. (2016)
       Chromosome Res., 24: 1-4.

 Chromosome mis-segregation and cytokinesis failure in trisomic human cells.
       Nicholson J.M., Macedo J.C., Mattingly A.J., Wangsa D., Camps J., Lima V., Gomes A.M., Dória S., Ried T.,
       Logarinho E., and Cimini D. (2015)
       eLife, 4: e05068.

 Genomic instability: crossing pathways at the origin of structural and numerical chromosome changes.
       Russo A., Pacchierotti F., Cimini D., Ganem N.J., Genescà A., Natarajan A.T., Pavanello S.,
       Valle G., and Degrassi F. (2015)
       Environ. Mol. Mutagenesis, 56: 563-580.

 Link between aneuploidy and chromosome instability.
       Nicholson J.M. and Cimini D. (2015)
       Internat. Rev. Cell Mol. Biol., 315: 299-317.

 The mitotic origin of chromosomal instability.
       Bakhoum S.F., Silkworth W.T., Nardi I.K., Nicholson J.M., Compton D.A., and Cimini D. (2014)
       Curr. Biol., 24: R148-149.

 Cancer karyotypes: survival of the fittest.
       Nicholson J.M. and Cimini D. (2013)
       Front. Oncol., 3: 148.

 How mitotic errors contribute to karyotypic diversity in cancer.
       Nicholson J.M. and Cimini D.
       Adv. Canc. Res. , 112: 43-75.

 Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment
       and chromosome mis-segregation in cancer cells.

       Silkworth W.T., Nardi I., Scholl L.M., and Cimini D. (2009).
       PloS ONE, 4(8): e6564.

 Histone hyperacetylation in mitosis prevents sister chromatid separation and produces chromosome
       segregation defects.

       Cimini D., Mattiuzzo M., Torosantucci L., and Degrassi F. (2003).
       Mol. Biol. Cell., 14: 3821-3833.

 Differences in malsegregation rates obtained by scoring ana-telophases or binucleate cells.
       Cimini D., Tanzarella C., and Degrassi F. (1999).
       Mutagenesis, 14: 563-568.

 Topoisomerase II inhibition in mitosis produces numerical and structural chromosomal aberrations
       in human fibroblasts.

       Cimini D., Antoccia A., Tanzarella C., and Degrassi F. (1997).
       Cytogenet. Cell Genet., 76: 61-67.

 Effects of 5-azacytidine on the centromeric region of human fibroblasts studied by CREST staining
       and in situ hybridization on cytokinesis-blocked cells.

       Cimini D., Tanzarella C., and Degrassi F. (1996).
       Cytogenet. Cell Genet., 72: 219-224.