Chromosome Segregation and Chromosome Instability
Chromosomes missegregated into micronuclei contribute to chromosomal instability
by missegregating
at the next division.
He B., Gnawali N., Hinman A.W., Mattingly A.J., Osimani A.,
Cimini D.
(2019).
Oncotarget, 10: 2660-2674.
Exogenous glucocorticoids amplify the costs of infection by reducing resistance
and tolerance,
but effects are mitigated by co-infection.
Schoenle L.A., Moore I.T., Dudek A.M., Garcia E.B., Mays M., Haussmann M.F.,
Cimini
D., Bonier F.
(2019).
Proceedings of the Royal Society B: Biological Sciences, 286: 20182913.
Single-cell analysis reveals that chronic silver nanoparticle exposure induces
cell division defects
in human epithelial cells.
Garcia E.B., Alms C., Hinman A.W., Kelly C., Smith A., Vance M., Loncarek J., Marr L.C.,
Cimini D.
(2019).
International Journal of Environmental Research and Public Health, 16: 2061.
Environmental stresses induce karyotypic instability in colorectal cancer cells.
Tan Z., Chan Y.J.A., Chua Y.J.K., Rutledge S.D., Pavelka N.,
Cimini D.,
Rancati G. (2019).
Molecular Biology of the Cell, 30: 42-55.
Chromosome segregation: the bigger they come, the harder they fall.
Baudoin N.C. and
Cimini D. (2018).
Current Biology, 28: R665–R667.
A guide to classifying
mitotic stages and mitotic defects in fixed cells.
Baudoin N.C. and
Cimini D. (2018).
Chromosoma, 127: 215-227.
Fluid shear stress
impacts ovarian cancer cell viability, subcellular organization, and promotes
genomic instability.
Hyler A.R., Baudoin N.C., Brown M.S., Stremler M.A.,
Cimini D., Davalos
R.V., Schmelz E.M. (2018).
PLoS ONE, 13: e0194170.
Near-tetraploid cancer
cells show chromosome instability triggered by replication stress and exhibit
enhanced invasiveness.
Wangsa D., Quintanilla I., Torabi K., Vila-Casadesús M., Ercilla A., Klus G., Yuce Z.,
Galofré C.,
Cuatrecasas M., Lozano J.J., Agell N.,
Cimini
D., Castells A., Ried T., and Camps J. (2018).
FASEB Journal, 3502-3517.
Transient ALT
activation protects human primary cells from chromosome instability induced by
low chronic oxidative stress.
Coluzzi E., Buonsante R., Leone S., Asmar A.J., Miller K.L.,
Cimini D., and
Sgura A. (2017).
Scientific Reports, 7: 43309.
Chromosome bridges
maintain kinetochore-microtubule attachments throughout mitosis
and rarely break during anaphase.
Pampalona J., Roscioli E., Silkworth W.T., Bowden B., Genescà A., Tusell L., and
Cimini D. (2016)
PLoS ONE, 11:e0147420.
The centrosome: a
multifaceted cellular weapon against chromosome instability.
Guarguaglini G. and
Cimini D. (2016)
Chromosome Res., 24: 1-4.
Chromosome
mis-segregation and cytokinesis failure in trisomic human cells.
Nicholson J.M., Macedo J.C., Mattingly A.J., Wangsa D., Camps J., Lima V., Gomes A.M., Dória
S., Ried T.,
Logarinho E., and
Cimini D. (2015)
eLife, 4: e05068.
Genomic instability:
crossing pathways at the origin of structural and numerical chromosome
changes.
Russo A., Pacchierotti F.,
Cimini D., Ganem N.J., Genescà A., Natarajan
A.T., Pavanello S.,
Valle G., and Degrassi F. (2015)
Environ. Mol. Mutagenesis, 56: 563-580.
Link between aneuploidy
and chromosome instability.
Nicholson J.M. and
Cimini D. (2015)
Internat. Rev. Cell Mol. Biol., 315: 299-317.
The mitotic origin of
chromosomal instability.
Bakhoum S.F., Silkworth W.T., Nardi I.K., Nicholson J.M., Compton D.A., and
Cimini
D. (2014)
Curr. Biol., 24: R148-149.
Cancer karyotypes:
survival of the fittest.
Nicholson J.M. and
Cimini D. (2013)
Front. Oncol., 3: 148.
How mitotic errors contribute to karyotypic diversity in cancer.
Nicholson J.M. and
Cimini D.
Adv. Canc. Res. , 112: 43-75.
Multipolar
spindle pole coalescence is a major source of kinetochore mis-attachment
and chromosome mis-segregation in
cancer cells.
Silkworth W.T., Nardi I., Scholl L.M., and
Cimini D. (2009).
PloS ONE, 4(8): e6564.
Histone
hyperacetylation in mitosis prevents sister chromatid separation and produces
chromosome
segregation defects.
Cimini D., Mattiuzzo M., Torosantucci L., and Degrassi F. (2003).
Mol. Biol. Cell., 14: 3821-3833.
Differences
in malsegregation rates
obtained by scoring ana-telophases or binucleate cells.
Cimini D., Tanzarella C., and Degrassi F. (1999).
Mutagenesis, 14: 563-568.
Topoisomerase
II inhibition in mitosis produces numerical and structural chromosomal
aberrations
in human fibroblasts.
Cimini D., Antoccia A., Tanzarella C., and Degrassi F. (1997).
Cytogenet. Cell Genet., 76: 61-67.
Effects
of 5-azacytidine on the centromeric region of human fibroblasts studied by CREST
staining
and in situ hybridization on
cytokinesis-blocked
cells.
Cimini D., Tanzarella C., and Degrassi F. (1996).
Cytogenet. Cell Genet., 72: 219-224.